LipoMorph by Antaeus Labs: Advanced Thermogenesis Activation Complex!
Antaeus Labs is proud to present Lipo-Morph, a weight-management supplement at the cutting edge of scientific understanding of human physiology. Lipo-Morph is the first “fat burner” supplement to specifically target all known modifiable mechanisms of white fat browning, and both brown and beige fat activation.
Understanding your enemy: Fat
Ordinary white fat stores energy in the form of fat droplets, one droplet per adipocyte, which can be broken down by lipolysis into free fatty acids which are circulated into the blood stream and transported to the fuel-requiring tissue where they undergo beta-oxidation to acetyl-CoA which can be used to generate energy through the Krebs cycle. The energy stored in white fat, when liberated, is primarily burned to produce ATP to power cells.
Unfortunately, modern Western diet and lifestyle habits (consisting of excessive caloric intake typically coupled with insufficient physical activity) can cause an excessive accumulation of both subcutaneous and visceral white adipose tissue (WAT) that can have numerous adverse effects on health and health markers.
Brown fat is a thermogenic tissue that turns energy (stored as triglycerides) into heat. It’s found in abundance in hibernating mammals. When the temperature drops, animals like bears “go to sleep for the winter”. They’re able to survive by burning reserves of energy which have been stored as white and brown fat. The heat produced by the brown fat, which is activated by the cold, maintains the essential core body temperature of the animal through the winter months.
It’s also found in high quantities in babies, but is present in much smaller amounts in adult humans. Unlike adults, babies are unable to regulate their own temperature by, say, putting on a coat or moving to a warmer room, so their ability to regulate their own temperature is more vital to their survival. Accordingly, they have greater amounts of brown fat which is widely distributed viscerally and subcutaneously, decreasing as age increases until as adults brown fat is largely limited to small deposits in the lower neck and supraclavicular region. These deposits are suspected to be useful in cold weather for warming blood as it flows to the brain. Brown fat appears brown in color because of the high density of mitochondria and excellent blood supply. Certain natural conditions, like endurance exercise and cold temperatures, can encourage the human body to produce and/or activate brown fat.
Thermogenesis in brown fat is mediated by thermogenin, also known as uncoupling protein 1 (UCP1). UCP1 is specific to the mitochondria of brown fat, and functions as a proton transporter, uncoupling oxidative phosphorylation from ATP synthesis and allowing the resulting energy to dissipate in the form of heat. The thermogenic effect of UCP1 is known as “non-shivering thermogenesis”.
In addition to classical brown fat, which originates from the same progenitor cells as muscle tissue, brown-like fat expressing the same thermogenic genes as brown fat can be made from regular mature white fat cells and their precursors. This brown-from-white fat is variously termed “brite” or “beige” fat, and the process of its creation known as “browning” of white fat. Whereas excessive white adipose tissue (WAT) impairs health, the recruitment and activation of brown and beige adipose tissue is currently being investigated as being potentially beneficial in the fight against obesity and metabolic disorders.
Regulators of Brown & Beige Fat
Natural regulators of brown and beige fat include external conditions like cold temperatures, and exercise, as well as internal mechanisms like thyroid hormones, beta-adrenergic hormones, retinoids, PPARγ and PPARα agonists, and the liver X receptor.
Exercise & Peroxisome Proliferator-Activated Receptors
Exercise has a number of positive health benefits, particularly regular, sustained aerobic exercise. One of the mediators of the positive metabolic effects of endurance exercise is peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). PGC-1α is a transcriptional coactivator that binds to and activates transcription factors that regulate the genes involved in energy metabolism. It has a number of functions in the body, including influencing muscle fiber type determination, controlling lactate metabolism, and increasing amino acid breakdown in response to exercise stimulus.
One of the products of amino acid breakdown in muscle tissue is β-aminoisobutyric acid (BAIBA), arising from the degradation of thymine and valine. BAIBA is believed to act as a messenger signalling molecule, released into the blood stream by exercise, that helps the body respond to demands for more energy by increasing β-oxidation of fatty acids. It’s also recently been discovered that BAIBA can induce white adipose tissue (WAT) to express brown fat-specific genes – including the all-important thermogenic UCP1.
Cold Temperatures & Beta-Adrenergic Hormones
The thermogenic effects of brown fat can be activated in several ways; in hibernating animals and babies the trigger is cold temperatures. Cold temperatures trigger a release of norepinephrine into the blood stream, an adrenergic hormone which has several important roles, one of which is to activate brown fat via the beta-3 adrenergic receptor (β3 adrenoreceptor).
Unlike other beta adrenergic receptors, which are widely distributed about the body, being found in cardiac tissue, skeletal and smooth muscle, and adipose tissue, distribution of β3 receptors are restricted to a few tissues – including brown fat, where activation increases energy expenditure.
Brown fat also expresses heat-sensing receptors of its own. The receptor that detects cold temperatures is the cold and menthol receptor 1 (CMR1), more formally known as the transient receptor potential cation channel subfamily M member 8 (TRPM8).The transient receptor potential channels (TRPs) help the peripheral nervous system detect important variations in temperature; TRPV1 detects and regulates heat, but can also be activated by things like capsaicin (which is why chili peppers taste hot), and TRPM8 detects cold but can also be activated by compounds like menthol (which is why peppermint tastes cold).
Thermogenesis in brown fat can be triggered by TRPM8 activation or norepinephrine release (β3 adrenoreceptor agonism). Human white adipose tissue also expresses the cold-sensing receptor TRPM8, which, when activated, transdifferentiates to a brown-like phenotype expressing UCP-1.
What is it?
BAIBA is a naturally occurring amino acid, a product of the metabolism of thymine and valine. 
Levels of BAIBA are increased significantly by endurance exercise, a result of PGC1α-mediated amino acid breakdown. 
1) BAIBA exerts its effects on hepatocytes (liver cells) and white adipocytes (fat cells) through PPARalpha (PPARα). 
2) PPARα regulates the use of fat as a source of energy. 
What Is It?
Octopamine is a naturally-occurring endogenous amine found in plants such as bitter orange as well as vertebrates and invertebrates. 
1) Octopamine is a selective agonist of the mammalian beta-3 adrenergic receptor (β3adrenoreceptor). 
2) Beta-3-adrenoceptor agonism is one of the primary regulators of brown fat activationand beige fat recruitment. 
What is it?
(−)-Menthol is a naturally-occurring compound found in wild mint and peppermint.
1) Menthol is an agonist of the TRPM8 receptor, also known as the cold and menthol receptor.
2) TRPM8 activation triggers thermogenesis in brown fat by mimicking long-term cold exposure. 
3) Menthol is also an agonist of transient receptor potential A1 (TRPA1) in humans,  another thermosensitive (cold-sensing) receptor that has been linked to brown fat activation in animal models. 
Ilex Kudingcha Extract
What Is It?
Ilex Kudingcha (Ilex kaushue) is a species of the holly genus of plants. In China the leaves are dried and brewed into a tea called Kuding. The bitter-tasting Kuding tea has been used for millennia as a traditional chinese medicine (TCM) for a variety of ailments.
1) Kuding has the ability to suppress the activity of the Liver X Receptor beta (LXRβ) through antagonist activity. 
2) LXRβ antagonism results in decreased transcriptional activity of the enzyme sterol regulatory element-binding protein-1c (SREBP-1c), which is required for lipogenesis. 
What is it?
One of the forms of vitamin A is retinol. This animal-derived retinoid is essential for healthy skin, bone, and teeth. The main active metabolite of vitamin A is retinoic acid.
1) Retinoic acid binds to and activates the retinoic acid receptor (RAR).
2) The vitamin A metabolite 9-cis-retinoic acid is an endogenous ligand of the retinoid X receptor (RXR)
What Is It?
Fucoxanthin is a naturally-occurring xanthophyll found in brown algae and edible seaweed.
1) Some of fucoxanthin’s putative anti-obesity effects may be via downregulation of PPAR-γ.
What Is It?
Stearoyl vanillylamide is a naturally-occurring capsaicin analogue found in red pepper species. Capsaicin is responsible for the hot/burning feeling caused by chili peppers. Unlike capsaicin, stearoyl vanillylamide is nonpungent, meaning it does not impart the “spicy” or irritative effects of capsaicin.
1) Stearoyl vanillylamide, capsaicin and similar compounds activate the transient receptor potential cation channel V1 (TRPV1).
As a dietary supplement, take two capsules daily with food. We recommend taking one capsule with the first meal of the day and one capsule in the afternoon or evening with food. Users who weigh over 200 pounds may take three capsules per day if desired. Do not exceed four capsules in any 24 hour period.
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